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Introducing the Endurance Enhancement Phenomenon…...
Fizogen Precision
Technologies introduces the most technologically
advanced endurance supplement ever to hit the
market! Combining Magnesium Orotate, Di-Arginine
Orotate and Potassium Orotate in a time released
delivery system, EPOVAR promises
to help you achieve your peak potential in training
and competition. Need to be convinced that this
is for real? Simply read the scientific abstract
from the amazing study found on the bottom of
this page**, which demonstrates the awe-inspiring
power of EPOVAR. Plus it is
extremely safe for long-term use! The effects
are something you must experience for yourself.
Get the edge on your competition or just make
your training feel a whole lot easier. Get started
on EPOVAR today!
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EPOVAR
Contains the following powerful ingredients:
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OROVAR-CC
This highly potent
performance enhancement agent contains specialized nutrients
combined with patent-pending salts of Orotic Acid. The
EPOVAR formulation is simply the biggest advancement
in endurance enhancing supplementation! Whether the
VO2 MAX elevating effects are compared to anything Legal
or illegal… Orovar-CC simply promises to transform
the face of endurance supplements forever! Di-Arginine
Orotate is utilized as a primary ingredient to help
maximize Orotic Acid blood levels and deliver rapid
vasodilatation throughout the body to help oxygenate
and supply nutrients to the heart, lungs and skeletal
muscle during periods of prolonged stress from high
intensity aerobic and anaerobic output. This cumulative
effect may enhance VO2 Max levels to unprecedented heights!
EPOVAR may simply enhance your performance and training
threshold to a level you have never known! Magnesium
Orotate is then utilized in combination with Di-Arginine
Orotate to further amplify the powerful desired hormonal
response. Magnesium Orotate, itself the subject of countless
clinical studies, shows its awe-inspiring power for
enhancing endurance markers in the paragraph below**.
The Orotic Acid component of Orovar-CC is your new secret
weapon against your competition! Orotic Acid is provided
within the EPOVAR formula in calculated and exact dosing
protocol to deliver unduplicatable effectiveness! Lastly,
Orovar-CC contains Potassium Orotate to further fuel
the incredible endurance effects! Orovar-CC is simply
the most powerful endurance-enhancing compound ever
invented when combined with serious training and a well
balanced diet. Get ready to experience an endurance
supplement that finally works... BRACE YOURSELF FOR
EPOVAR!
MAGNESIUM
OROTATE…
The endurance performance enhancement revolution has
begun!
**A study was conducted
using 23 competitive tri-athletes; all subject to 4
weeks of supplementation with 17mmol/d (4.5 Grams) Magnesium
Orotate or a placebo during a double blind randomized
controlled study. They then each competed in an event
including a 500-meter swim a 5-km run and a 20-km bicycle
race after supplementation. Blood was collected before,
between and after the events for assaying energy stress
and membrane metabolism. Compared with the controls,
running, swimming and cycling time decreased in the
Magnesium Orotate group. Serum insulin decreased 65%
in the MO group and increased 39% in the controls (significant).
Serum glucose concentrations increased 118% in the MO
group and 87% in the control group (significant). Venous
O2 partial pressure increased 208% in the MO group as
opposed to 126% in the controls (significant). Venous
CO2 partial pressure after the bicycle race decreased
74% in controls as compared to 66% in the MO group (significant).
Blood leukocyte count increased from 5.81/nL to 9.10/nL
in the MO group as opposed to 5.92/nL to 11.0/nl in
the controls (significant). Blood proton concentration
decreased 98% in controls compared to 90% in the MO
group (significant). Serum cortisol was reduced in the
MO group before between and after the event when compared
with the controls. CK catalytic concentration after
the test was elevated 122% in the MO group compared
to 140% in the controls. This study points to a substantially
reduced stress response to training, altered glucose
utilization and positive stress-induced modifications
of energy and hormone metabolism, which did not affect
competitive potential.
**On
the significance of magnesium in extreme physical stress.
Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:197-202.
Golf SW, Bender S, Gruttner J. Institute of Clinical
Chemistry and Pathobiochemistry, University Medical
School, Justus-Liebig-University, Giessen, Germany.
Additional
references for orotic acid and endurance enhancement
potential:
In humans, Magnesium Orotate may improve
exercise tolerance in patients with coronary artery
disease and in trained athletes (Cardiovascular Drugs
and Therapy 1998,12 (Suppl2),147-152 (conference sponsored
by the International Society of Cardiovascular Pharmacotherapy
Minuskin ML., 1981. Nitrogen retention,
muscle creatine and orotic acid excretion in traumatized
rats fed arginine and glycine enriched diets.
Effects of magnesium orotate on exercise
tolerance in patients with coronary heart disease. Cardiovasc
Drugs Ther. 1998 Sep;12 Suppl 2:153-6. Cardiovasc Drugs
Ther. 1998 Sep;12 Suppl 2:153-6.
Orotic acid as a metabolic agent.
Vestn Ross Akad Med Nauk. 2002;(2):39-41. Vestn Ross
Akad Med Nauk. 2002;(2):39-41. Review. Russian.
Magnesium orotate in myocardial and
neuronal protection. Rom J Intern Med. 1999 Jan-Mar;37(1):91-7.
Rom J Intern Med. 1999 Jan-Mar;37(1):91-7.
Mechanism of cardioprotective effect
of orotic acid. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl
2:159-70. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:159-70.
Quantitative evaluation of the anxiolytic
and nootropic effects of potassium orotate in a wide
range of doses. Karkishchenko NN, Khaitin MI.
Farmakol Toksikol. 1986 Jan-Feb;49(1):14-6. Russian.
Anxiolytic effect of potassium orotate.
Karkishchenko NN, Khaitin MI. Farmakol Toksikol. 1983
Jul-Aug;46(4):68-71. Russian.
Safety data (MSDS) for Orotic acid.
Physical & Theoretical ChemistryLaboratoryOxfordUniversity.
Dec. 2002: 1-2
Orotate uptake and metabolism by human
erythrocytes.
Adv Exp Med Biol. 1984;165 Pt A:367-71.
Metabolic supplementation with orotic
acid and magnesium orotate. Rosenfeldt FL. Cardiovasc
Drugs Ther 1998 Sep 12 Suppl 2:147-52.
Effects of orotic acid ingestion on
urinary and blood parameters in humans. Robinson, JL
et al. Nutrition Research 1983. 3: 407-415.
Bovine milk orotic acid: Variability
and significance for human nutrition. Robinson, JL et
al. J. Dairy Sci. 1983. 63: 865-871.
Orotic acid content of infant formulas.
Durshlag RP, et al. Am. J. Clin. Nutr. 1980 33:2192-2193
Cardiovascular Drugs and Therapy 1998,
12, 147-152; Journal of Molecular and Cellular Cardiology
1997, 29, 3239-3250.
Oral administration of OA.Acta Vitaminologica
1962, 16, 193-198 (language NA)
A review of clinical and experimental
studies into the mechanism of action of OA as a metabolic
agent (Vestnuk Rossiiskoi akademii meditsinskikh/Rossiiskaia
akademiia meditsinskikh navk 2002,2,39-41 (Russian)
Mechanism of cardioprotective effect
of orotic acid .Rosenfeldt FL, Richards SM, Lin Z, Pepe
S, Conyers RA. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl
2:159-70.
Cardioprotection by orotic acid: metabolism
and mechanism of action. Richards SM, Conyers RA, Fisher
JL, Rosenfeldt FL. J Mol Cell Cardiol. 1997 Dec;29(12):3239-50.
Sensitivity of the recently infarcted
heart to cardioplegic arrest. Beneficial effect of pretreatment
with orotic acid. Newman MA, Chen XZ, Rabinov M, Williams
JF, Rosenfeldt FL. J Thorac Cardiovasc Surg. 1989 Apr;97(4):593-604.
Nieper HA. The anti-inflammatory and
immune-inhibiting effects of calcium orotate on bradytrophic
tissues. Agressologie. 1969;10(4):349-57. Available
as article #CM14 from the A. Keith Brewer International
Science Library at (608) 647-6513
Nieper HA. The clinical applications
of lithium orotate. A two years study. Agressologie.
1973;14(6):407-11. Available as article #CM12 from the
A. Keith Brewer International Science Library at (608)
647-6513
Nieper HA. The clinical effect of
calcium-diorotate on cartilage tissue, the specific
function dependent upon the pentose metabolism of bradytrophic
tissue . Z prūkt Geriatrie. 1973;3(4):82-9.
English translation available as article #CM29 from
the A. Keith Brewer International Science Library at
(608) 647-6513
Rundles RW, Brewer SS Jr. Hematologic
responses in pernicious anemia to orotic acid. Blood.
1958;13(2):99-115.
Pasquali P, Landi L, Caldarera CM,
Marchetti M. Effects of orotic acid on dihydrofolate
dehydrogenase and on tetrahydrofolate-dependent enzymes
in the chick liver. Biochim Biophys Acta. 1968;158(3):482-4.
O’Sullivan WJ. Orotic acid.
Aust N Z J Med. 1973;3(4):417-22.
Connolly GP, Duley JA. Uridine and
its nucleotides: biological actions, therapeutic potentials.
Trends Pharmacol Sci. 1999;20(5):218-25.
Donohoe JA, Rosenfeldt FL, Munsch
CM, Williams JF. The effect of orotic acid treatment
on the energy and carbohydrate metabolism of the hypertrophying
rat heart. Int J Biochem. 1993;25(2):163-82.
Ferdinandy P, Fazekas T, Kadar E.
Effects of orotic acid on ischaemic/reperfused myocardial
function and glycogen content in isolated working rat
hearts. Pharmacol Res. 1998;37(2):111-4.
Villanyi P, Votin J, Rahlfs V. Arteriosclerosis,
myocardial infarct and blood lipids, their therapeutic
modification by magnesium orotate. Wien Med Wochenschr.
1970;120(5):76-83.
Jellinek H, Takacs E. Morphological
aspects of the effects of orotic acid and magnesium
orotate on hypercholesterolaemia in rabbits. Arzneimittelforschung.
1995;45(8):836-42.
Ouchi Y, Tabata RE, Stergiopoulos
K, Sato F, Hattori A, Orimo H. Effect of dietary magnesium
on development of atherosclerosis in cholesterol-fed
rabbits. Arteriosclerosis. 1990;10(5):732-7.
