Sports and Diet Supplements

Safety data (MSDS) for Orotic acid. Physical & Theoretical Chemistry Laboratory Oxford University. Dec. 2002: 1-2

Orotate uptake and metabolism by human erythrocytes. Adv Exp Med Biol. 1984;165 Pt A:367-71.

Metabolic supplementation with orotic acid and magnesium orotate. Rosenfeldt FL. Cardiovasc Drugs Ther 1998 Sep 12 Suppl 2:147-52.

Effects of orotic acid ingestion on urinary and blood parameters in humans. Robinson, JL et al. Nutrition Research 1983. 3: 407-415.

Bovine milk orotic acid: Variability and significance for human nutrition. Robinson, JL et al. J. Dairy Sci. 1983. 63: 865-871.

Orotic acid content of infant formulas. Durshlag RP, et al. Am. J. Clin. Nutr. 1980 33:2192-2193

Cardiovascular Drugs and Therapy 1998, 12, 147-152; Journal of Molecular and Cellular Cardiology 1997, 29, 3239-3250.

Oral administration of OA. Acta Vitaminologica 1962, 16, 193-198 (language NA)

MO supplementation (3000mg/day/90 days) in a randomized, placebo-controlled clinical pilot stydy was ineffective therapyt for idiopathic male infertility (Magnesium Research 2003,16,131-136).

A review of clinical and experimental studies into the mechanism of action of OA as a metabolic agent (Vestnuk Rossiiskoi akademii meditsinskikh/Rossiiskaia akademiia meditsinskikh navk 2002,2,
39-41 (Russian)

Mechanism of cardioprotective effect of orotic acid . Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:159-70.

Cardioprotection by orotic acid: metabolism and mechanism of action. J Mol Cell Cardiol. 1997 Dec;29(12):3239-50.

Sensitivity of the recently infarcted heart to cardioplegic arrest. Beneficial effect of pretreatment with orotic acid. J Thorac Cardiovasc Surg. 1989 Apr;97(4):593-604. Wohlhueter RM, McIvor RS, Plagemann PG. Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells. J Cell Physiol. 1980;104(3):309-19.

Nieper HA. The anti-inflammatory and immune-inhibiting effects of calcium orotate on bradytrophic tissues. Agressologie. 1969;10(4):349-57. Available as article #CM14 from the A. Keith Brewer International Science Library at (608) 647-6513 Nieper HA. The clinical applications of lithium orotate. A two years study. Agressologie. 1973;14(6):407-11. Available as article #CM12 from the A. Keith Brewer International Science Library at (608) 647-6513

Nieper HA. The clinical effect of calcium-diorotate on cartilage tissue, the specific function dependent upon the pentose metabolism of bradytrophic tissue . Z präkt Geriatrie. 1973;3(4):82-9. English translation available as article #CM29 from the A. Keith Brewer International Science Library at (608) 647-6513

Rundles RW, Brewer SS Jr. Hematologic responses in pernicious anemia to orotic acid. Blood. 1958;13(2):99-115.

Pasquali P, Landi L, Caldarera CM, Marchetti M. Effects of orotic acid on dihydrofolate dehydrogenase and on tetrahydrofolate-dependent enzymes in the chick liver. Biochim Biophys Acta. 1968;158(3):482-4.

O’Sullivan WJ. Orotic acid. Aust N Z J Med. 1973;3(4):417-22.

Connolly GP, Duley JA. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci. 1999;20(5):218-25.

Dodin G, Lalart D, Dubois JE. Role of magnesium cations in the yeast orotate phosphoribosyltransferase catalyzed reaction. Mechanism of the inhibition by Cu++ and Ni++ ions. J Inorg Biochem. 1982;16(3):201-13.

Donohoe JA, Rosenfeldt FL, Munsch CM, Williams JF. The effect of orotic acid treatment on the energy and carbohydrate metabolism of the hypertrophying rat heart. Int J Biochem. 1993;25(2):163-82.

Ferdinandy P, Fazekas T, Kadar E. Effects of orotic acid on ischaemic/reperfused myocardial function and glycogen content in isolated working rat hearts. Pharmacol Res. 1998;37(2):111-4.

Villanyi P, Votin J, Rahlfs V. Arteriosclerosis, myocardial infarct and blood lipids, their therapeutic modification by magnesium orotate. Wien Med Wochenschr. 1970;120(5):76-83.

Jellinek H, Takacs E. Morphological aspects of the effects of orotic acid and magnesium orotate on hypercholesterolaemia in rabbits. Arzneimittelforschung. 1995;45(8):836-42.

Ouchi Y, Tabata RE, Stergiopoulos K, Sato F, Hattori A, Orimo H. Effect of dietary magnesium on development of atherosclerosis in cholesterol-fed rabbits. Arteriosclerosis. 1990;10(5):732-7.

Dewar AJ, Reading HW. Effect of lithium administration on RNA metabolism in rat brain. Psychol Med. 1971;1(3):254-9.

Toxicological and metabolic investigations of the safey of N-x-lauroyl-L-arginine ethyl ester (LAE, a novel food preservative). Food Chem. Tox. 2004, 42, 245-59.