Sports and Diet Supplements

" Orotic acid is a naturally occurring vitamin that possesses both anabolic and uricosuric properties. Testing for it is not currently available since “normal” levels are undertermined." Yesalis, Charles E. ScD, Human Kinetics Publishers, Anabolic Steroids In Sport and Exercise, 1993, pg. 302

On the significance of magnesium in extreme physical stress. Golf SW, Bender S, Gruttner J. Institute of Clinical Chemistry and Pathobiochemistry, University Medical School, Justus-Liebig-University, Giessen, Germany.Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:197-202.

In humans, Magnesium Orotate may improve exercise tolerance in patients with coronary artery disease and in trained athletes (Cardiovascular Drugs and Therapy 1998,12 (Suppl2),147-152 (conference sponsored by the International Society of Cardiovascular Pharmacotherapy

Oral administration of OA (300mg/kg/day) for 4 weeks beginning on the 15th day of life to 10 infants caused a greater weight gain than in their twins used as matched controls on the same diet of human or cow milk. No effect was observed on total proteins or its fractions in the blood of these subjects (Acta Vitaminologica 1962, 16, 193-198

Effect of anabolic substances on the state of the individual components of the glutathione-ascorbic acid system. Farmakol Toksikol. 1980 Sep-Oct;43(5):607-9. Farmakol Toksikol. 1980 Sep-Oct;43(5):607-9. Russian.

Effect of potassium orotate and nerobol (methandrostenolone) on the nucleic acid metabolism in patients with pulmonary tuberculosis. Vrach Delo. 1974 Dec;(12):50-2. Russian. Vrach Delo. 1974 Dec;(12):50-2.

Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:153-6. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:153-6.

Moruzzi G, Viviani R, Marchetti M. Orotic acid as a “growth factor” for chickens and its relation to vitamin B12 and methionine. Biochem Z. 1960;333:318-27.

Orotic acid as a metabolic agent. Vestn Ross Akad Med Nauk. 2002;(2):39-41. Vestn Ross Akad Med Nauk. 2002;(2):39-41. Review. Russian.

In rats, addition of OA or methylorotic acid (100-240 mg/day) to a synthetic diet promoted the gowth of rats (Bitamin 1957,13,126-127 (language NA).

Influence of orotate on weight gain in rats (Acta Vitaminologica et enxzymologica 1969, 23, 14-18 (Italian).

In rats, OA (250mg/100g/day) significantly increased the rate of body weight increase of young rats. Osaka-shiritsu Daigaku Igaku Zasshi 1960, 9, 4199-4214 (language NA)

Magnesium orotate in myocardial and neuronal protection. Rom J Intern Med. 1999 Jan-Mar;37(1):91-7. Rom J Intern Med. 1999 Jan-Mar;37(1):91-7.

Mechanism of cardioprotective effect of orotic acid. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:159-70. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:159-70.

In rats, Orotic Acid or magnesium orotate (MO) improves the function of recently infracted hearts, and may protect against further ischemic stress by:(a)increasing plasma uridine, secondary to an effect on the liver(b) preventing depletion of adenine nucleotides in surviving myocardium (Cardiovascular Drugs and Therapy 1998, 12 159-170; Journal of Molecular and Cellular Cardiology 1997, 29, 3239-3250).

Quantitative evaluation of the anxiolytic and nootropic effects of potassium orotate in a wide range of doses. Karkishchenko NN, Khaitin MI. Farmakol Toksikol. 1986 Jan-Feb;49(1):14-6. Russian. Anxiolytic effect of potassium orotate. Karkishchenko NN, Khaitin MI. Farmakol Toksikol. 1983 Jul-Aug;46(4):68-71. Russian.

Biosynthesis of biogenic pyrimidines in anxiety and depressive states of different etiologies. Karkishchenko NN, Stradomskii BV, Makliakov IuS, Zaika VG. Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(4):73-4. Russian.

Influence of combined application of orotic acid and central stimulants on memory processes and participation of cholinergic mechanisms. Acta Physiol Pharmacol Bulg. 1981;7(1):25-32.

Improvement of shuttle-box avoidance by combinations of orotic acid and central stimulants. Yonkov D, Wetzel W, Matthies H, Roussinov K.
Psychopharmacology (Berl). 1981;73(4):399-401.

Psychophysiological effects of combined administration of pantogam and potassium orotate in patients with neurotic disorders. Ben'kovich BI, Gorshkova IA, Gershanovich II, Faizulloev AZ. Eksp Klin Farmakol. 2001 May-Jun;64(3):26-8. Russian.

Orotic acid in organic mental disorders. Med Monatsschr Pharm. Rischke R, Krieglstein J. 1991 Apr;14(4):120-1. German.

Nitrogen-stimulated orotic acid synthesis and nucleotide imbalance. Visek WJ. Cancer Res. 1992 Apr 1;52(7 Suppl):2082s-2084s.

Effect of pyridoxine, riboflavin, potassium orotate, folic and glutamic acids on the recovery of work capacity in sexually immature rats.Farmakol Toksikol. 1985 Jul-Aug;48(4):110-2. Russian.